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October 1, 2025

Supplementary Figure S4 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy

Paola Manara Austin D. Newsam Venu Venkatarame Gowda Saralamma Tyler Andrew Cunningham Drew Lazenby J.J.David Ho Marco Vincenzo Russo Abdessamad Youssfi Alaoui Dhanvantri Chahar Alicia Bilbao Martinez Nikolai Fattakhov Alexandra Marie Carbone Olivia Barbara Farag Alexa Marie Barroso Kyle Hoffman Francesco Maura Daniel Bilbao Jonathan H. Schatz

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Key Points

Zotatifin treatment significantly sensitizes DLBCL cells to ferroptosis, enhancing the potential effectiveness of CAR T-cell immunotherapy.
Key markers for apoptosis and ferroptosis were analyzed using immunoblotting, indicating critical molecular interactions.
The combination treatment of zotatifin with RSL3 or DMF demonstrates a stronger therapeutic effect in DLBCL cells.
This approach highlights the significance of targeting cap-dependent initiation to improve immunotherapeutic strategies.

Implication

Immunoblot analysis reveals that zotatifin enhances ferroptosis in DLBCL cells, suggesting improved CAR T-cell therapy efficacy.

Abstract

Immunoblot analysis of apoptosis and ferroptosis markers in DLBCL cells treated with zotatifin in combination with RSL3 or DMF.

Discussion

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Cite This Study

Manara et al. (2025) studied this question.

synapsesocial.com/papers/68de68f183cbc991d0a21a7a https://doi.org/10.1158/0008-5472.30255185

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S1 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
2Supplementary Figure S3 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
3Supplementary Figure S6 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
4Supplementary Figure S2 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
5Supplementary Figure S8 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025

Supplementary Figure S7 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
Supplementary Figure S5 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025
Data from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy2025