Supplementary Figure S4 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy

Key Points

• Zotatifin treatment significantly sensitizes DLBCL cells to ferroptosis, enhancing the potential effectiveness of CAR T-cell immunotherapy.
• Key markers for apoptosis and ferroptosis were analyzed using immunoblotting, indicating critical molecular interactions.
• The combination treatment of zotatifin with RSL3 or DMF demonstrates a stronger therapeutic effect in DLBCL cells.
• This approach highlights the significance of targeting cap-dependent initiation to improve immunotherapeutic strategies.