Supplementary Figure S1 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity

Key Points

• T-cells from 3xTg mice exhibit a significant advantage in opposing tumor growth compared to APP-PS1 mice.
• This finding suggests a potential link between aging stress, mitophagy, and enhanced antitumor immunity.
• The study highlights the role of amyloid-β precursor protein in improving immune responses against tumors.
• Further research is needed to explore the mechanisms underlying this protective advantage in T-cells.