Supplementary Figure S1 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity

This is a Experimental Study study.

Key Points

T-cells from 3xTg mice exhibit a significant advantage in opposing tumor growth compared to APP-PS1 mice.
This finding suggests a potential link between aging stress, mitophagy, and enhanced antitumor immunity.
The study highlights the role of amyloid-β precursor protein in improving immune responses against tumors.
Further research is needed to explore the mechanisms underlying this protective advantage in T-cells.

Study shows functional advantage of T-cells in 3xTg mice over APP-PS1, indicating improved antitumor immunity.

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Kassir et al. (2025) studied this question.

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