Supplementary Figure S5 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity

Key Points

• Fumarate supplementation effectively reverses aging-induced mitophagy in T-cells, enhancing their functionality.
• Old T-cells treated with fumarate show a restored transcriptional phenotype without impacting behavior.
• This analysis focuses on how amyloid-β precursor protein influences aging and antitumor immunity mechanisms.
• Fumarate's role suggests potential therapeutic pathways for improving immunity in aging populations.