Supplementary Figure S5 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity

Key Points

Fumarate supplementation effectively reverses aging-induced mitophagy in T-cells, enhancing their functionality.
Old T-cells treated with fumarate show a restored transcriptional phenotype without impacting behavior.
This analysis focuses on how amyloid-β precursor protein influences aging and antitumor immunity mechanisms.
Fumarate's role suggests potential therapeutic pathways for improving immunity in aging populations.

Supplementary Figure S5 demonstrates that fumarate improves antitumor immunity in aging T-cells, highlighting a crucial link.

Fumarate supplementation reverses aging-induced mitophagy and transcriptional phenotype in old T-cells without affecting mouse behavior.

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Kassir et al. (2025) studied this question.

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