Supplementary Figure S3 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity

Key Points

Inhibiting mitophagy improves antitumor immunity in aging T-cells, suggesting critical interactions in immune functions.
Aβ40 is sufficient but not necessary to inhibit mitophagy, highlighting distinct roles of amyloid-beta peptides.
The study employs analysis of aging T-cells to assess the effects of amyloid-β on mitophagy and immunity.
This research may inform future strategies for enhancing antitumor responses, especially in aging populations.

Supplementary Figure S3 reveals inhibiting mitophagy in aging T-cells and suggests potential immunotherapeutic targets.

Aβ40, but not Aβ42, is sufficient but not necessary to inhibit mitophagy in aging T-cells.

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Kassir et al. (2025) studied this question.

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