Supplementary Figure S2 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity

Key Points

Mitochondrial APP improves antitumor immunity by preventing mitophagy in aging T-cells.
ATAD3 shuttles CerS6 to mitochondria, impacted by the amyloid-β precursor protein.
Mitochondrial APP's role in fumarate depletion highlights its importance in immune response.
Understanding these mechanisms may lead to improved therapies targeting aging and immunity.

Research shows that mitochondrial APP prevents mitophagy in aging T-cells, suggesting enhanced antitumor immunity.

ATAD3 shuttles CerS6 to the mitochondria of aging T-cells and mitochondrial APP blocks this effect.

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Kassir et al. (2025) studied this question.

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