Supplementary Figure S4 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity

This is a Quantitative Study study.

Key Points

Improved antitumor immunity was noted in aged T-cells linked to mitochondrial regulation.
Flux metabolomics indicated significant metabolic alterations in old wild-type T-cells.
The study highlights the role of amyloid-β precursor protein in modulating mitophagy.
Findings suggest potential therapeutic pathways targeting metabolism and immunity.

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Analysis reveals amyloid-β precursor protein enhances antitumor immunity in aging T-cells, suggesting metabolic shifts via mitophagy.

Metabolic changes in old WT T-cells as measured by flux metabolomics.

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Kassir et al. (2025) studied this question.

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