Supplementary Figure S2 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy | Synapse
October 2, 2025Open Access
Supplementary Figure S2 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy
Key Points
Targeting NRF2 translation increases lymphoma cell sensitivity to ferroptosis and CAR T-cell immunotherapy.
Key metrics reveal that zotatifin treatment significantly alters the translational landscape and enhances therapeutic response.
Analysis combined immunoblots, pSILAC data, and GSEA enrichment to assess molecular impacts of treatment.
These findings suggest that inhibiting NRF2 translation may improve responses to existing lymphoma therapies.
Abstract
Integrated analysis of translation and transcription upon zotatifin treatment, including immunoblots, TMT-pSILAC data, and GSEA enrichment.