Supplementary Figure S4 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy | Synapse
October 2, 2025
Supplementary Figure S4 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy
Key Points
Zotatifin treatment significantly sensitizes DLBCL cells to ferroptosis, enhancing the potential effectiveness of CAR T-cell immunotherapy.
Key markers for apoptosis and ferroptosis were analyzed using immunoblotting, indicating critical molecular interactions.
The combination treatment of zotatifin with RSL3 or DMF demonstrates a stronger therapeutic effect in DLBCL cells.
This approach highlights the significance of targeting cap-dependent initiation to improve immunotherapeutic strategies.
Abstract
Immunoblot analysis of apoptosis and ferroptosis markers in DLBCL cells treated with zotatifin in combination with RSL3 or DMF.