Supplementary Figure 3 from SPP1+ Tumor-Associated Macrophages Drive Immunotherapy Resistance via CD8+ T-cell Dysfunction in Clear-Cell Renal Cell Carcinoma

Key Points

• Tumor-associated macrophages contribute to CD8 T-cell dysfunction, promoting immunotherapy resistance in clear-cell renal cell carcinoma.
• Analysis showed distinct characteristics of TAMs and T cells using CyTOF and flow cytometry in ccRCC biopsies.
• Assessment focused on the interaction between immune cells in the tumor microenvironment, highlighting potential therapeutic targets.
• Results indicate that modifying TAM behavior may enhance the effectiveness of existing immunotherapy strategies.

Abstract