Supplementary Figure S5 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy | Synapse
October 2, 2025Open Access
Supplementary Figure S5 from Blocking NRF2 Translation by Inhibition of Cap-Dependent Initiation Sensitizes Lymphoma Cells to Ferroptosis and CAR T-cell Immunotherapy
Key Points
Blocking nrf2 translation increases sensitivity to ferroptosis in lymphoma cells, leading to improved treatment outcomes.
The study shows that rocaglates inhibit nrf2 translation via cap-dependent initiation, backed by multiple assays.
Immunoblots and luciferase assays demonstrate the efficacy of rocaglates in reducing nrf2 levels in cancer cells.
By sensitizing lymphoma cells to ferroptosis, this approach may enhance the effectiveness of car t-cell immunotherapy.
Abstract
Rocaglates inhibit NRF2 translation via cap-dependent initiation, supported by CCLE correlation, immunoblots, luciferase assays, and siRNA knockdown.