Differential Performance of Polygenic Score for Coronary Artery Disease Based on Coronary Artery Calcium Between Men Living With and Without HIV

BACKGROUND: on coronary artery calcium (CAC), a measure of subclinical atherosclerosis, by HIV serostatus. METHODS: for log-transformed CAC and area under the curve (AUC) for binary outcomes (absence/presence of CAC, absence of CAC AS=0 versus low CAC AS=1-100 or high CAC AS >100). RESULTS: =0.22). CONCLUSIONS: to CAC showed lower performance for PLWH than PWOH men. Further research is needed to develop accurate risk prediction models with clinical utility in all patients.