Differential Performance of Polygenic Score for Coronary Artery Disease Based on Coronary Artery Calcium Between Men Living With and Without HIV

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  Figure 1. Lower performance of PRS for CAC category in PLWH. A, Comparing low CAC (<100) with absence of CAC (CAC=0), the AUC in PWOH was 0.747 (95% CI, 0.677–0.816) while the AUC in PLWH was 0.714 (95% CI, 0.654–0.775), with a P difference=0.493. B, Comparing high CAC (>100) with absence of CAC (CAC=0), the AUC in PWOH was 0.865 (95% CI, 0.819–0.912) and the AUC in PLWH was 0.785 (95% CI, 0.733–0.837), with a P difference=0.025. AUC indicates area under the [receiver operating characteristic] curve; CAC, coronary artery calcium; PLWH, people living with HIV; PRS, polygenic risk score; and PWOH, people living without HIV.