A polygenic score for coronary artery disease showed lower performance for predicting coronary artery calcium in men living with HIV compared to men without HIV.
Observational
Does the performance of a Polygenic Score for Coronary Artery Disease based on Coronary Artery Calcium differ between men living with and without HIV?
Polygenic risk scores for CAD may have reduced predictive performance for subclinical atherosclerosis in men living with HIV, highlighting the need for population-specific risk models.
p-value: p=0.22
BACKGROUND: on coronary artery calcium (CAC), a measure of subclinical atherosclerosis, by HIV serostatus. METHODS: for log-transformed CAC and area under the curve (AUC) for binary outcomes (absence/presence of CAC, absence of CAC AS=0 versus low CAC AS=1-100 or high CAC AS >100). RESULTS: =0.22). CONCLUSIONS: to CAC showed lower performance for PLWH than PWOH men. Further research is needed to develop accurate risk prediction models with clinical utility in all patients.
Wojcik et al. (Wed,) conducted a observational in Coronary Artery Disease and HIV. Polygenic Score for Coronary Artery Disease vs. Men without HIV was evaluated on Coronary artery calcium (CAC) and area under the curve (AUC) for binary outcomes (p=0.22). A polygenic score for coronary artery disease showed lower performance for predicting coronary artery calcium in men living with HIV compared to men without HIV.