Cortical Bone-Mimetic Composite with Sustained Biomechanical Stability and Longitudinal Osteo-guiding Capacity for Functional Reconstruction of Large Segmental Bone Defects

The regenerative repair of critical-sized load-bearing bone defects remains challenging in achieving stable graft fixation and timely restoration of biomechanical integrity without excessive biotherapeutics. Here, we develop a biomimetic polyamino...