Pulse Explore Journal Club Debates Trending Researchers

Join discussions, follow papers, and never miss your next session.

Download on theApp Store

Home Explore Journal Club Trending

⌘+K

Sex-specific associations of intrapancreatic fat deposition with incident type 2 diabetes | Synapse

December 2, 2025Open Access

View Full Paper

Sex-specific associations of intrapancreatic fat deposition with incident type 2 diabetes

XWXuechen Wang YYYucheng Yang SHShumeng Han

Key Points

IPFD is associated with increased risk of incident T2D in both sexes, highlighting its significance.
The study indicates IPFD provides predictive value for future type 2 diabetes, independent of other fat types.
Cohort analysis shows IPFD is linked to T2D risk, regardless of BMI in men and women, emphasizing its role in diabetes prediction.
Highlighting the distinct impact of intrapancreatic fat on diabetes risk may enable better risk assessment strategies.

Abstract

In this large-scale cohort study, IPFD is associated with incident T2D independent of BMI, hepatic fat and visceral fat in men and independent of BMI and hepatic fat in women. The results suggest that IPFD is of additional predictive value for future T2D.

Ask AI

Helpful

Bookmark

Share

View Full Paper

Ask AI

Helpful

Bookmark

Share

View Full Paper

Cite This Study

Wang et al. (Fri,) studied this question.

synapsesocial.com/papers/692e3d8d6c9b3ab28c1877e6 https://doi.org/https://doi.org/10.1038/s43856-025-01221-x

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1A systematic evaluation of the performance and properties of the UK Biobank Polygenic Risk Score (PRS) Release2024 · 139 citations
2Non-invasive methods for imaging hepatic steatosis and their clinical importance in NAFLD2021 · 252 citations
3Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance: a nuclear magnetic resonance study2010 · 270 citations
4Clinical implications of fatty pancreas: Correlations between fatty pancreas and metabolic syndrome2009 · 309 citations
5Sex differences in regional adipose tissue depots pose different threats for the development of Type 2 diabetes in males and females2022 · 45 citations