Sex-specific associations of intrapancreatic fat deposition with incident type 2 diabetes

Xuechen Wang; Yucheng Yang; Shumeng Han; Zijun Liu; Fan Ping; Wei Li; Lingling Xu; Huabing Zhang; Yuxiu Li; Xuechen Wang; Yucheng Yang; Shumeng Han; Zijun Liu; Fan Ping; Wei Li; Lingling Xu; Huabing Zhang; Yuxiu Li

doi:10.1038/s43856-025-01221-x

Key Points

IPFD is associated with increased risk of incident T2D in both sexes, highlighting its significance.
The study indicates IPFD provides predictive value for future type 2 diabetes, independent of other fat types.
Cohort analysis shows IPFD is linked to T2D risk, regardless of BMI in men and women, emphasizing its role in diabetes prediction.
Highlighting the distinct impact of intrapancreatic fat on diabetes risk may enable better risk assessment strategies.

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Implication

Observational analysis reveals intrapancreatic fat increases type 2 diabetes risk in men and women, suggesting diagnostic value beyond BMI.

Abstract

In this large-scale cohort study, IPFD is associated with incident T2D independent of BMI, hepatic fat and visceral fat in men and independent of BMI and hepatic fat in women. The results suggest that IPFD is of additional predictive value for future T2D.

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Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/692e3d8d6c9b3ab28c1877e6 https://doi.org/10.1038/s43856-025-01221-x

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Sex-specific associations of intrapancreatic fat deposition with incident type 2 diabetes

Key Points

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Implication

Abstract

Discussion

Cite This Study

Sex-specific associations of intrapancreatic fat deposition with incident type 2 diabetes

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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