Intrapancreatic fat deposition shows distinct regional and compartmental associations with obesity and diabetes

The objective of this study is to identify determinants of fat deposition in anatomically distinct regions of the pancreas. One hundred donor pancreases without active pancreatic cancer were histologically examined across distinct regions for intralobular and interlobular fat. Predictors of fat deposition in the pancreatic head and tail were determined. Tail intralobular fat was greater than head intralobular fat, and female donors had greater fat across all measured regions and compartments. The distribution of fat in the head and tail varied depending on the presence of obesity or diabetes. Patterns of intrapancreatic fat deposition (IPFD) and associated risk factors can vary by anatomical region.