December 8, 2025Open Access

Retroperitoneal vNOTES approach in early-stage endometrial cancer: a feasibility cohort with a contemporaneous laparoscopic comparison

Key Points

The retroperitoneal vNOTES approach shows feasible outcomes in early-stage endometrial cancer, enhancing recovery with reduced postoperative pain.
Patients undergoing vnotes experienced significant improvements in both recovery time and pain management compared to traditional methods.
Cohort analysis compared the vNOTES technique to laparoscopy, showing promising early results that warrant further validation through larger prospective studies.
Validation of these findings in prospective studies is crucial to ascertain long-term oncologic outcomes beyond short-term observations.

Abstract

The retroperitoneal vNOTES approach appears to be a feasible and safe technique for the surgical staging of early-stage endometrial cancer, providing perioperative benefits including shorter operative time, reduced postoperative pain, and faster recovery. The comparative findings with conventional laparoscopy should be interpreted as exploratory and require validation in larger prospective studies. Oncologic outcomes remain short-term and should be confirmed through long-term follow-up.

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Cite This Study

Halisçelik et al. (Mon,) studied this question.

synapsesocial.com/papers/694020e22d562116f28faa69 https://doi.org/https://doi.org/10.1186/s12893-025-03385-8

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