Glutathione-Activatable Bola Dendrimers Mediate Tumor-Specific Cytosolic siRNA Delivery via Dynamic Thiol-Disulfide Exchange

Key Points

• This research aims to enhance tumor-specific delivery of siRNA through engineered dendrimers.
• Engineered glutathione-responsive bola dendrimers for delivering siRNA
• Examined cytosolic delivery efficiency
• Analyzed the role of dynamic thiol-disulfide exchange in delivery process.
• Demonstrated improved siRNA delivery specifically to tumor cells
• Showed release of siRNA in the cytosol facilitated by glutathione
• Highlighted the potential of RNAi-driven therapies in precision cancer treatment.