In the prebiotic era, the emergence of life was governed by the physical self-assembly of fatty acid vesicles. These open systems possessed a "second chance"—the ability to reorganize after physical disruption. Modern biological cells, however, have traded this thermodynamic resilience for high-level biochemical complexity. This paper argues that we are facing a global "physical time bomb." Inert nanoparticles, while chemically non-toxic, act as physical stressors that deform cellular membranes, triggering undefined biochemical cascades and oncogenic shifts. By ignoring the physics of the membrane in favor of downstream biochemistry, modern medicine may be overlooking the root cause of systemic cellular failure.
Peter Mikuláš (Sat,) studied this question.