What question did this study set out to answer?

To evaluate the effectiveness of BioFire FilmArray pneumonia testing in outpatient surveillance bronchoscopies for lung transplant recipients.

January 14, 2026Open Access

Evaluation of BioFire FilmArray® Pneumonia PCR Multiplex Panel Testing in Routine Outpatient Surveillance Bronchoscopies After Lung Transplant

Key Points

To evaluate the effectiveness of BioFire FilmArray pneumonia testing in outpatient surveillance bronchoscopies for lung transplant recipients.
Retrospective analysis of outpatient bronchoscopies in lung transplant recipients from October 2023 to April 2025.
Data collected on demographics, test results, symptoms, and antibiotic prescriptions.
Concordance between PCR panel and bacterial culture assessed using Cohen’s kappa.
215 surveillance bronchoscopies were conducted in 58 lung transplant recipients.
PCR identified bacterial targets in 10.6% of cases, while bacterial cultures were positive in 9.3%.
High concordance of 96% was observed between PCR and culture results.

Abstract

Abstract Background Lung transplant recipients (LTRs) undergo surveillance bronchoscopies (SB) at regular intervals post-transplant to detect rejection/infection early 70% were male. Most (96%) LTRs were double lung transplants. Median time from transplant to SB was 197 days (IQR 190.8). Only 7% of SBs occurred at a time when a patient had a clinical suspicion of possible LRTI. The PCR resulted with a positive target in 20.5% of BAL specimens,10.6% PCRs had a detected bacterial target, the PCR panel adds cost without clear benefit. Disclosures Hannah Imlay, MD, MS, Recursion pharmaceutical: Stocks/Bonds (Public Company)

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