Nutrigenetics is an emerging field of study that deals with the correlation between one’s genetic make-up and the efficiency and functioning of their nutrient uptake based on the dietary factors, which influences disease risk and progression. It offers a potential framework for personalized nutrition in cancer prevention and management. Research findings show that polymorphisms in genes involved in processes such as DNA repair, nutrient metabolism, inflammation and oxidative stress may alter individual responses to nutritional factors. This leads to individual differences in their susceptibility to cancer and how they respond to treatment. This review consolidates existing studies on the role of nutrigenetics in cancer, highlighting key gene-nutrient interactions linked to various common malignancies. It also investigates findings from observational studies, clinical trials and forthcoming applied research. The translation of nutrigenetics into therapeutics will require multi-disciplinary collaboration and the incorporation into evidence-based guidelines. This approach ensures safe, effective and fair personalised nutrition strategies in oncology. Key Words : Nutrigenetics, personalized nutrition, polymorphisms, cancer susceptibility, gene-nutrient interactions, multi-disciplinary collaborations
Shreya Sudhir Menon (Tue,) studied this question.