What question did this study set out to answer?

To explore how Langerhans cell histiocytosis can be mistaken for Hodgkin lymphoma in clinical settings.

January 20, 2026Open Access

Langerhans Cell Histiocytosis Masquerading as Hodgkin Lymphoma

I(International Journal of Medical Science and Advanced Clinical Research (IJMACR)

Key Points

To explore how Langerhans cell histiocytosis can be mistaken for Hodgkin lymphoma in clinical settings.
Review of clinical cases showcasing LCH and its presentation as Hodgkin lymphoma.
Analysis of patient demographics focusing on age and clinical symptoms.
Evaluation of relevant diagnostic criteria for distinguishing LCH from Hodgkin lymphoma.
LCH cases reported were often misdiagnosed as Hodgkin lymphoma due to overlapping symptoms.
Most cases involved children under 10, but some adult cases were noted.
Identifying LCH correctly is crucial for appropriate treatment and management strategies.

Abstract

Abstract Langerhans cell histiocytosis (LCH) is a rare clonal proliferative disorder characterized by the accumulation of abnormal Langerhans-type dendritic cells1. Although it is classified as a neoplasm, it exhibits a wide spectrum of clinical presentations, ranging from isolated lesions to disseminated, multisystem involvement. LCH primarily affects the paediatric population, with the majority of cases diagnosed in children under the age of 10. However, occurrences in adults, though less frequent, have also been documented. Recent research indicates that LCH arises from myeloid precursor dendritic cells, reinforcing its characterization as a neoplastic disorder rather than a solely reactive process.2

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