BMP9 Modulates IL-33 Signaling to Mitigate EndMT in Pulmonary Arterial Hypertension.

Key Points

• This research aims to investigate how bmp9 influences il-33 signaling and its effects on endmt in pulmonary arterial hypertensive cells.
• Assessed the effect of bmp9 on il-33 signaling in pulmonary artery endothelial cells (paecs)
• Evaluated sst2 expression levels in response to bmp9 treatment
• Analyzed the impact of bmp9 on the process of endmt under il-33 stimulation
• Bmp9 upregulates sst2 expression in paecs exposed to il-33
• Bmp9 mitigates endmt induced by il-33
• Targeting il-33 signaling may serve as a promising therapeutic strategy for pulmonary arterial hypertension.