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Findings reveal that bmp9 protects against il-33-induced endmt in pulmonary arterial cells, suggesting a therapeutic avenue.
BMP9 plays a protective role against IL-33-induced EndMT in PAECs by upregulating sST2 expression and neutralizing IL-33, suggesting that targeting the IL-33 signaling pathway may represent a promising therapeutic strategy to mitigate EndMT in PAH.
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Becher et al. (2026) studied this question.
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