PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
January 24, 20262 citationsOpen Access

BMP9 Modulates IL-33 Signaling to Mitigate EndMT in Pulmonary Arterial Hypertension.

View Full Paper
CBClarissa BecherEGE. GroeneveldRQRozenn Quarck

Key Points

  • This research aims to investigate how bmp9 influences il-33 signaling and its effects on endmt in pulmonary arterial hypertensive cells.
  • Assessed the effect of bmp9 on il-33 signaling in pulmonary artery endothelial cells (paecs)
  • Evaluated sst2 expression levels in response to bmp9 treatment
  • Analyzed the impact of bmp9 on the process of endmt under il-33 stimulation
  • Bmp9 upregulates sst2 expression in paecs exposed to il-33
  • Bmp9 mitigates endmt induced by il-33
  • Targeting il-33 signaling may serve as a promising therapeutic strategy for pulmonary arterial hypertension.

Abstract

BMP9 plays a protective role against IL-33-induced EndMT in PAECs by upregulating sST2 expression and neutralizing IL-33, suggesting that targeting the IL-33 signaling pathway may represent a promising therapeutic strategy to mitigate EndMT in PAH.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Becher et al. (2026) studied this question.

synapsesocial.com/papers/69746050bb9d90c67120a278https://doi.org/10.1161/hypertensionaha.125.24916
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1BMP9 attenuates IL-33 signaling and prevents endothelial-to-mesenchymal transition in pulmonary arterial hypertension2024
  2. 2BMP9 regulates the endothelial secretome to drive pulmonary hypertension2025 · 3 citations
  3. 3Effects of Modulating BMP9, BMPR2, and AQP1 on Bmp-Signaling in Human Pulmonary Microvascular Endothelial Cells2024 · 1 citations
  4. 4BMPR2 Dosage Gates BMP9/10 Signaling Output in Pulmonary Artery Endothelium2026 · 1 citations
  5. 5Solving an enigma: the BMP-9/10 axis as a key regulator of pulmonary vascular resilience2026