September 8, 2026European Respiratory Journal
Solving an enigma: the BMP-9/10 axis as a key regulator of pulmonary vascular resilience
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Discussion
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Implication
Review demonstrates bimodal regulation of vascular tone in pulmonary disorders, suggesting therapeutic tuning rather than pathway activation is key.
Key Points
- To elucidate the dual regulatory mechanisms of the BMP-9/10 signaling axis in maintaining pulmonary vascular resilience and driving diverse vascular pathologies.
- Synthesized molecular and clinical evidence evaluating BMP-9 and BMP-10 signaling across ALK1, BMPRII, and endoglin receptor complexes.
- Analyzed pathophysiological mechanisms across pulmonary arterial hypertension, hepatopulmonary syndrome, and hereditary hemorrhagic telangiectasia.
- Characterized the BMP-9/10 axis as a bimodal regulatory system where both signaling deficiency and hyperactivation disrupt endothelial quiescence and vascular tone.
- Demonstrated that balancing aberrant activin and BMP pathways via ligand traps such as sotatercept therapeutically stabilizes pulmonary vascular integrity more effectively than linear pathway activation.
Cite This Study
Guignabert et al. (2026) studied this question.