The natural history of interstitial lung disease in common variable immunodeficiency

Extract Granulomatous lymphocytic interstitial lung disease (gl-ILD) occurs particularly in patients with inborn errors of immunity, typically common variable immunodeficiency (CVID), a heterogeneous antibody deficiency syndrome. [1] Beside recurrent respiratory tract infections, [2] nearly 50% of CVID patients develop inflammatory and lymphoproliferative complications. [3, 4] of which gl-ILD affects up to half [5, 6].