In patients with hypertension and obstructive sleep apnea syndrome, the apnea-hypopnea index was significantly negatively correlated with the reactive hyperemia index (r = -0.58).
Cross-Sectional (n=47)
Open-label
No
Does the reactive hyperemia index correlate with endothelial dysfunction markers and AHI in patients with hypertension and OSAHS?
In patients with hypertension and OSAHS, the reactive hyperemia index (RHI) strongly correlates with AHI and endothelial dysfunction markers, suggesting its utility as a non-invasive indicator of vascular injury.
Effect estimate: r = -0.58 (95% CI -0.75 to -0.35)
p-value: p=<0.001
Objective Currently, there is a lack of clinical studies on how to stratify endothelial dysfunction based on the severity of co-existing hypertension and OSAHS. This evidence gap hinders clinicians’ ability to accurately assess disease burden and determine the best timing and intensity of intervention for these high-risk patients. This study aimed to investigate the impact of hypertension combined with OSAHS on vascular endothelial function. Methods Patients aged 35–60 years with hypertension and OSAHS were consecutively recruited from the outpatient department of the Department of Cardiology at the Chengdu Pidu District People's Hospital, from July 1, 2023, to December 31, 2023. AHI, RHI and endothelial damage-related markers Von Willebrand Factor (VWF), Vascular Endothelial Growth Factor (VEGF), and Endothelial Microparticles (EMPs) were measured. Routine examination data were collected. Results The correlation analysis between AHI, RHI, and hypertension grade and hypertension stage showed correlation coefficients less than 0.2, indicating almost no linear relationship. The correlation coefficient between AHI and RHI was −0.58 ( P 0.001). The correlation coefficients between AHI and VWF, VEGF, and EMPS were 0.56 ( P 0.001), 0.49 ( P 0.001), and 0.66 ( P 0.001). The correlation coefficients between RHI and VWF, VEGF, and EMPS were −0.62 ( P 0.001), −0.63 ( P 0.001), and −0.67 ( P 0.001). The RHI showed significant inverse associations with the studied variables.A 1-SD increase in AHI, vWF, VEGF, and EMPs was associated with a decrease in RHI of 0.02, 0.62, 0.63, and 0.67 units, respectively. ( β = –0.02, adjusted β = –0.60, P 0.01; β = –0.62, adjusted β = –0.64, P 0.01; β = −0.63, adjusted β = –0.64, P 0.01; β = −0.67, adjusted β = –0.71, P 0.01). Conclusion In patients with hypertension combined with OSAHS, RHI can be used as an important indicator in routine tests of vascular endothelial function to predict the degree of vascular endothelial injury.
Yu et al. (Fri,) conducted a cross-sectional in Hypertension and obstructive sleep apnea syndrome (OSAHS) (n=47). In patients with hypertension and obstructive sleep apnea syndrome, the apnea-hypopnea index was significantly negatively correlated with the reactive hyperemia index (r = -0.58).
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