Polygenic risk and rare variants in endotypes of idiopathic pulmonary fibrosis: a genetic analysis of population-based and case–control cohorts

Key Points

• Genetic analysis reveals significant associations with idiopathic pulmonary fibrosis endotypes, indicating risk factors.
• A combination of polygenic risk scores and rare variants were examined across diverse cohorts to explore relationships.
• The observational analysis evaluates genetic data from population-based and case-control cohorts, providing insights into disease mechanisms.
• Findings may enable targeted interventions in idiopathic pulmonary fibrosis, highlighting the role of genetics in disease progression.