Association of 18 FFlortaucipir–PET and Plasma p-Tau217 With Tau Neuropathology in Alzheimer Disease and Other Neurodegenerative Disorders

Key Points

• This research aims to examine the relationship between flortaucipir-PET, plasma p-tau217, and tau neuropathology in various neurodegenerative conditions.
• Utilized flortaucipir-PET imaging to assess tau pathology in subjects.
• Measured plasma levels of p-tau217 related to tau pathology.
• Compared findings between Alzheimer disease and other neurodegenerative disorders.
• Flortaucipir-PET showed high specificity for diagnosing Alzheimer disease.
• Plasma p-tau217 had limited sensitivity for detecting early tau co-pathology outside of Alzheimer disease.