Epigenetic regulation by oleacein mitigates IL-1β-induced inflammation in human SW982 synovial cells

Key Points

• The study aims to investigate how oleacein affects inflammation and oxidative stress in human synovial cells.
• Used SW982 human synovial cells exposed to IL-1β, LPS, and ATP to induce inflammation.
• Analyzed epigenetic regulation and inflammatory pathways including MAPK, NF-κB, and Keap1/Nrf2/HO-1.
• Measured levels of cytokines, MMPs, and COX-2/PGE2 after treatment with oleacein.
• OLA significantly reduced inflammation markers induced by IL-1β.
• Inhibition of MAPK and NF-κB pathways was observed.
• Reduction in cytokines, MMPs, and COX-2/PGE2 levels indicated decreased inflammatory response.