CHA2DS2-VASc vs. CHA2DS2-VA regarding their stroke risk stratifications in patients with atrial fibrillation: insights from the GLORIA-AF registry

Abstract Background Whether the adoption of CHA2DS2-VA score, the sex-independent version of the CHA2DS2-VASc score is beneficial for stratifying risk of stroke in patients with atrial fibrillation (AF) remains controversial. Purpose To compare CHA2DS2-VASc and CHA2DS2-VA in terms of thromboembolic risk stratification. Methods Utilising the data from the global, multicentre and prospective GLORIA-AF Registry Phase III, we compared the performances of CHA2DS2-VA and CHA2DS2-VASc in stratifying the risk of ischemic stroke and thromboembolism (TE) and compared the risk of ischemic stroke and TE, and second, the use of oral anticoagulants between male and female patients with AF. Results A total of 21,260 AF patients with available data were included in the analysis (Age: mean ± SD, 70.2±10.3 years, 44.9% Female). Overall, female patients were less likely prescribed with OAC compared to males (OR:0.90, 95%CI: 0.83-0.97). A significant interaction (p0.001) between sex and age was observed, with a lower likelihood of receiving OAC among younger female patients (Figure 1). The risk of ischemic stroke (HR:1.14, 95%CI: 0.85-1.53) and TE (HR: 1.02, 95%CI: 0.82-1.26) was similar between male and female patients. The predictive ability of the two scores was similar for both outcomes: TE (AUC:0.641, 95%CI: 0.585-0.697 vs AUC:0.636, 95%CI: 0.580-0.692; p=0.593) and ischemic stroke (AUC:0.660, 95%CI: 0.582-0.739 vs AUC:0.646, 95%CI: 0.568-0.725; p=0.847) (Figure 2). There was a possible interaction between sex and age observed, with a higher risk of TE in younger female patients (p=0.051) (Figure 1). Conclusions CHA2DS2-VA score had similar overall predictive performance for thromboembolic events compared to CHA2DS2-VASc score. The role of female sex in the management and outcomes of patients with AF may differ according to age, with a higher risk of TE in younger female patients.