Orexin dual receptor antagonist attenuates neurological deficits possibly via PI3K/Akt/mTOR pathway activation in sleep-deprived stroke rats

Key Points

• The aim is to investigate whether orexin dual receptor antagonists can reduce neurological deficits in sleep-deprived stroke rats and explore associated signaling pathways.
• Administered almorexant to sleep-deprived stroke rats
• Assessed neurological deficits through behavioral tests
• Evaluated changes in PI3K/Akt/mTOR signaling pathways
• Almorexant treatment led to reduced neurological deficits in stroke rats
• Activation of the PI3K/Akt/mTOR pathway was observed
• Potential role in managing post-stroke insomnia was suggested