Animal study shows orexin dual receptor antagonist improves outcomes in sleep-deprived stroke rats, suggesting therapeutic potential.
Almorexant was associated with attenuation of SD-exacerbated ischemic brain injury in rats, accompanied by alterations in PI3K/Akt/mTOR signaling, suggesting DORAs may have potential relevance for the management of post-stroke insomnia.
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Wang et al. (2026) studied this question.
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