Enhancing clomipramine antidepressive effect using nanocomplexes via different routes of administration: A comparative study.

Key Points

• To compare the effects of clomipramine administered via different routes on its antidepressant activity.
• Compared intranasal and oral clomipramine administration.
• Assessed antidepressant activity and neurological toxicity.
• Utilized clomipramine-loaded nanocomplexes in trials.
• Intranasal route showed enhanced antidepressant activity compared to oral administration.
• Clomipramine nanocomplexes alleviated neurological toxicity effectively.