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Research Paper | Synapse

February 10, 2026

JAK2 pathogenic variants in ischemic stroke: low prevalence and pre-screening model.

Key Points

Investigate the prevalence of JAK2 mutations in ischemic stroke and develop a predictive model.
Analyzed JAK2 V617F mutation prevalence in ischemic stroke cases.
Developed a predictive model to identify at-risk individuals.
Employed a precision medicine approach to genetic screening.
Found JAK2 V617F mutation prevalence at 0.4% in ischemic stroke patients.
Developed a model that may reduce reliance on extensive genetic testing.

Abstract

Despite low prevalence (0.4%), JAK2 V617F mutation represents a clinically actionable stroke subtype with distinct pathophysiology. The prediction model offers a precision medicine approach, potentially reducing the need for comprehensive genetic testing.

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Authors

J

Jialu Zhao

S

Siqi Ge

S

Shujun Gao

Actions

Institutions

Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Beihang University

References and Citations

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Cite this study

Zhao et al. (Sat,) studied this question.

synapsesocial.com/papers/698acad77c832249c30ba51c — DOI: https://doi.org/10.1007/s00415-026-13658-8