What question did this study set out to answer?

The aim is to synthesize new pyrazole compounds and evaluate their antimicrobial properties.

synapse

⌘+K

synapse

⌘+K

February 10, 2026Open Access

Synthesis and antimicrobial activity of 5- (2'-n-butyl-4'-chloro-1'-H-imidazol-5'-yl) -3-aryl-4, 5-dihydro-1-H/1-acetyl/1-phenyl-pyrazoles

Key Points

The aim is to synthesize new pyrazole compounds and evaluate their antimicrobial properties.
Synthesis of various pyrazole derivatives (2a-2j, 3a-3j, 4a-4j)
Assessment of antimicrobial activity against Gram-positive and Gram-negative bacteria
Characterization of compounds using IR, 1HNMR, mass spectra, and TLC
Novel pyrazole compounds were successfully synthesized and characterized.
Certain compounds exhibited promising antimicrobial activity against both Gram-positive and Gram-negative bacteria.
Antifungal activity was also assessed, with varied results.

Abstract

5-(2’-n-butyl-4’-chloro 1’-H-imidazol- 5’-yl)-3-aryl-4, 5-dihydro-1-H-pyrazoles. (2a-2j); 1-5’-(2”-n-butyl-4”- chloro-1”-H-imidazol-5”-yl)-3’-Aryl-4’, 5’-dihydro-1’-H-pyrazol-1-yl-ethanones. (3a-3j); 5-(2’-n-butyl-4’-chloro-1’-H-imidazol-5’-yl)-3-Aryl-1-phenyl-4, 5-dihydro-1-H-pyrazoles. (4a-4j) have been synthesized. The products have been assayed for their antimicrobial activity against Gram +ve bacteria and Gram –ve bacteria and antifungal activity. The products have been characterised by IR, 1HNMR, Mass Spectra and TLC.

Mark Helpful

Bookmark

Relay

View Full Paper