Design and Antimicrobial evaluation of 1-(2-(2,3,5-triphenylcyclopenta-2,4-dien-1-yl)ethyl)piperazine and their derivatives

Key Points

• The research aims to design new piperazine derivatives and evaluate their antimicrobial activity.
• Synthesis of six 1,2,4,5-tetrasubstituted imidazoles through multicomponent cyclo-condensation.
• Screening for antibacterial activity against S. aureus, S. typhi, E. coli, and Pseudomonas.
• Screening for antifungal activity against A. niger, C. albicans, Rhizopus sp, and Mucor.
• The synthesized compounds demonstrated antibacterial effects against all tested strains.
• Enhanced antifungal activity was observed for the synthesized derivatives.