Data and Code for NCOMMS-25-57165A

this is the data and code depository for the paper "Generalization of fear learning is shaped by inhibitory sensory processing in mice", NCOMMS-25-57165. miasma. zip ; contains custom-written imaging analysis software used in this article. miasmadocumentation. docx ; detailed description of files and analysis steps for miasma. xls. zip ; contains the numerical data used in the findings. rstats. zip ; contains the stats codes written in rstudio. description of files in xls: - habituation. xls: dataset for habituation/dishabituation experiment. - mobility. xls: dataset for mobility and mean calcium increase after drug application, in imaging experiments. - all the animals are listed with their groups and mobility scores for each odor. - sheet O includes OSN animals, sheet G for PG cells, sheet M for mitral. "PRD" isolates paired animals. ALL and ALLSHORT has all the animals, latter in short format. - openfield. xls: dataset for openfield experiments. - detection: accuracy of ethovision, mobility: active time of the animals. center-zone2: percentage of time animals spent in each zone. - dists: mean distance from each zone, all danger: areas adjacent to CS+. , all safe: areas adjacent to no odor. - sheet "testingᵣep" includes interactable representative graphs for each point made in the paper along with additional ones. - sheet "testdist" isolated data of distances used to run stats. - percentages. xls: dataset for calcium findings, change in df/f ater drug application. - experimental specifics of all animals listed from B to E. - odor: presented odor, roi: ROI number, max: change in df/f of peak fluorescence, maxtime: time of peak, time1-5: peak within time section, offvol/area: offset metrics. - sheets are named according to cell type of animal. ᵣep includes interactable graphs for findings presented. - peaks. xls: same as percentage, but divided by peaks rather than just percentages. - block: 1, before application; 2, after application. - spatial: dataset for spatial analysis. - maxₚre: peak before drug, maxₚost: peak after drug, perc: change in df/f - roiₓ/y: centroid location of the ROI, refₓ/y: centroid location of the max responding CS+ glomerulus of specific animal. - eucl: euclidian distance between the ROI and peak CS+ ROI, micron: pixel converted to microns based on lens used. - overlap: 1 if this ROI is overlapping with any other, top50: 1 if this roi is a top 50 responding ROI. - m400: 1 if ROI is within 400 microns of peak CS+ ROI. description of files in rstats: *all files include a comment for which excel file to run and what to change in order to get the specific subsection of the analysis. - calciumₘobilitycorrelation: Fig 2K. - compareₚercentages: Fig 2 D-J. - mobilityₐcrossₒdors: Fig 1C. - mobilityₛex: Fig 1C, sex differences. - noceiling: Fig S2. - openfdistances: Fig 1D, Fig 4G-H. - overlapglom: Fig 3C-D. - proximityCS+: Fig 3E. - habituation: Fig 5C-D.