What does this research mean for the field?

METTL3-mediated m6A modification regulates the circINTS4/miR-146b-3p axis, influencing pathogenicity and inflammatory responses in rheumatoid arthritis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Examine how METTL3-mediated m6A modification affects the circINTS4/miR-146b-3p axis in rheumatoid arthritis and its implications for disease severity.

March 6, 2026Inflammation0 citationsOpen Access

METTL3-Mediated m6A Regulation of CircINTS4/miR-146b-3p Axis in Rheumatoid Arthritis

SLShu Li MZMengYu Zhang SLSiyu Liang

Key Points

Examine how METTL3-mediated m6A modification affects the circINTS4/miR-146b-3p axis in rheumatoid arthritis and its implications for disease severity.
Investigated METTL3 function in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS)
Analyzed circINTS4 role as a sponge for miR-146b-3p
Assessed the correlation between circINTS4 and RA disease severity
CircINTS4 significantly modulates RA-FLS pathogenicity
miR-146b-3p acts as a target of circINTS4, influencing inflammatory responses
Demonstrated the potential of circINTS4 as a biomarker for RA severity

Abstract

Our findings reveal that METTL3-mediated m6A modification regulates the circINTS4/miR-146b-3p axis, modulating RA-FLS pathogenicity and inflammatory responses. CircINTS4 acts as a molecular sponge for miR-146b-3p and serves as a promising biomarker for RA disease severity. This study provides new insights into the role of m6A methylation and circRNA-miRNA networks in RA, highlighting their potential as diagnostic and therapeutic targets.

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