Comparative study of the effects of subcutaneously administered umbilical cord-derived mesenchymal stem cells and exosomes derivatives on wound healing in a chemical burn model of alkaline-induced skin burns

Key Points

• This study aims to compare the effects of umbilical cord-derived mesenchymal stem cells and their exosomes on wound healing in a chemical burn model.
• Conducted a chemical burn model using alkaline-induced skin burns.
• Administered umbilical cord-derived mesenchymal stem cells (HucMSC) and exosomes (Exo-HucMSC) subcutaneously.
• Monitored healing progress to evaluate treatment effects on wound closure and angiogenesis.
• Both HucMSC and Exo-HucMSC treatments accelerated the healing of chemical burns.
• Exosomes promoted early-phase angiogenesis, aiding initial healing.
• HucMSCs contributed to better long-term wound closure compared to exosomes.