What question did this study set out to answer?

This research aims to evaluate the clinicopathological profiles and treatment outcomes of rare sarcoma subtypes, specifically focusing on Ewing's sarcoma.

March 12, 2026Open Access

250eP Clinicopathological profiles and real-world outcomes of rare sarcoma subtypes: A single-center experience from a resource-limited setting

MJM.J.H. JoudaCairo University

Key Points

This research aims to evaluate the clinicopathological profiles and treatment outcomes of rare sarcoma subtypes, specifically focusing on Ewing's sarcoma.
Single-center observational study conducted in a resource-limited setting
Patients received a median radiation dose of 50.4 Gy
Outcomes measured included local control, overall survival, disease-free survival, and toxicity levels
Local control rate at 3 years was 70%
Overall survival for non-metastatic patients at 3 years was 85%
Disease-free survival at 3 years was 78%
Acute toxicities were mainly Grade I-II, with 10% experiencing Grade III-IV toxicities

Abstract

patients, with a median dose of 50.4Gy.The local control rate at 3 years was 70 %.The 3 year overall survival (OS) and disease-free survival (DFS) of the non-metastatic patients were 85 % and 78%, respectively.Acute toxicities were predominantly Grade I-II, while Grade III-IV toxicities were observed in 10 % of patients.Conclusions: Radiotherapy in Ewings sarcoma remains an important modality for achieving local control, particularly in unresectable tumors or positive-margin disease.Acceptable toxicity and favorable survival outcomes highlight the importance of multidisciplinary management.

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