What question did this study set out to answer?

To illustrate the coexistence and treatment approach for severe aplastic anemia and lymphoplasmacytic lymphoma in an elderly patient.

March 12, 2026Open Access

Severe aplastic anemia concurrent with lymphoplasmacytic lymphoma/Waldenström's macroglobulinemia: A case report

Key Points

To illustrate the coexistence and treatment approach for severe aplastic anemia and lymphoplasmacytic lymphoma in an elderly patient.
Clinical evaluation of symptoms such as progressive dyspnea.
Bone marrow biopsy to confirm aplastic anemia and evaluate for lymphoma.
Genetic analysis for MYD88 mutation detection.
Sequential treatment using cyclosporine, eltrombopag, and rituximab.
Bone marrow biopsy confirmed hypoplastic marrow with abnormal lymphoid cells.
MYD88 p.V204F mutation supported lymphoma diagnosis.
Treatment improved symptoms related to both aplastic anemia and lymphoma.

Abstract

A 79-year-old female presented with progressive dyspnea. A bone marrow biopsy revealed hypoplastic marrow with abnormal lymphoid cells. A genetic analysis revealed a MYD88 p.V204F mutation, supporting the diagnosis of lymphoplasmacytic lymphoma/Waldenström's macroglobulinemia (LPL/WM). Additional evaluations established a concomitant diagnosis of aplastic anemia (AA). Treatment prioritized AA with cyclosporine and eltrombopag. Subsequently, the LPL/WM was treated with rituximab monotherapy. This sequential treatment resulted in a symptomatic improvement.

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Cite This Study

Okuda et al. (Thu,) studied this question.

synapsesocial.com/papers/69b25adb96eeacc4fcec901d https://doi.org/https://doi.org/10.2169/internalmedicine.6790-25

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