What question did this study set out to answer?

This analysis aims to compare the effectiveness of extended-release versus oral naltrexone in treating alcohol use disorder.

March 15, 2026

Comparative Effectiveness of Naltrexone Formulations in Alcohol Use Disorder: An Updated Meta-Analysis

Key Points

This analysis aims to compare the effectiveness of extended-release versus oral naltrexone in treating alcohol use disorder.
Conducted a meta-analysis of existing studies on naltrexone formulations.
Examined treatment persistence and healthcare utilization metrics between XR-NTX and oral NTX.
Identified factors influencing treatment efficacy, including formulation type.
Patients on XR-NTX demonstrated higher treatment persistence compared to those on oral NTX.
No significant differences were found in healthcare utilization, including emergency department visits and hospitalizations.

Abstract

This meta-analysis suggests higher treatment persistence among patients with AUD receiving XR-NTX versus oral NTX, underscoring formulation as a key factor in persistence and retention. However, alcohol-related healthcare utilization metrics, including ED visits and hospitalizations, showed no significant between-group differences. Further pragmatic trials accounting for patient preferences, sex-specific outcomes, and barriers to care accessibility are needed.

Mark Helpful

Bookmark

Relay