Characterisation of the Novel HLA‐DRB1*13:376 Allele by Next Generation Sequencing

Key Points

• The aim is to characterize the novel HLA‐DRB1*13:376 allele.
• Utilized next generation sequencing to analyze the allele
• Compared sequences of HLA‐DRB1*13:376 and HLA‐DRB1*13:86
• Identified nucleotide differences at specific positions
• Found a non‐synonymous nucleotide difference at position 71 in exon 2
• Confirmed unique sequence for HLA‐DRB1*13:376 distinct from HLA‐DRB1*13:86