Characterisation of the Novel HLA‐DRB1*13:376 Allele by Next Generation Sequencing

Julien Lion; Claire Le Boucq De Rupilly; Judith Desoutter; Nicolas Guillaume

doi:10.1111/tan.70674

March 1, 2026HLA

Characterisation of the Novel HLA‐DRB1*13:376 Allele by Next Generation Sequencing

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Key Points

The aim is to characterize the novel HLA‐DRB1*13:376 allele.
Utilized next generation sequencing to analyze the allele
Compared sequences of HLA‐DRB1*13:376 and HLA‐DRB1*13:86
Identified nucleotide differences at specific positions
Found a non‐synonymous nucleotide difference at position 71 in exon 2
Confirmed unique sequence for HLA‐DRB1*13:376 distinct from HLA‐DRB1*13:86

Implication

Characterization reveals a single nucleotide difference in the HLA‐DRB1*13:376 allele compared to HLA‐DRB1*13:86, indicating potential implications in immunogenetics.

Abstract

HLA‐DRB1*13:376 differs from the HLA‐DRB1*13:86 allele by one non‐synonymous nucleotide at position 71 in exon 2.

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Cite This Study

Lion et al. (2026) studied this question.

synapsesocial.com/papers/69b5ff8083145bc643d1c289 https://doi.org/10.1111/tan.70674

View at Publisher

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Characterisation of the Novel HLA‐DRB1*13:376 Allele by Next Generation Sequencing

Key Points

Implication

Abstract

Discussion

Cite This Study

Characterisation of the Novel HLA‐DRB1*13:376 Allele by Next Generation Sequencing

Key Points

Implication

Abstract

Discussion

Cite This Study

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