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February 1, 2026HLA

Identification of the Novel HLA‐DRB1*13:366 Allele by Sanger Dideoxy Nucleotide Sequencing

Cheng Yan Fan Dan Zhang N. Liu Tie Sun Yan Jun Jia

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Key Points

To identify and characterize the novel HLA‐DRB1*13:366 allele based on its genetic differences.
Used Sanger dideoxy nucleotide sequencing to analyze genetic variations.
Focused on exon 2 of the HLA-DRB1 gene.
Compared the new allele to the known HLA‐DRB1*13:214 allele.
Identified three nucleotide substitutions in codons 26, 28, and 30.
Established the unique sequence of HLA‐DRB1*13:366 as distinct from HLA‐DRB1*13:214.
Contributed to the understanding of genetic diversity in the HLA gene.

Implication

Genetic analysis identifies the novel HLA‐DRB1*13:366 allele, suggesting genetic diversity implications.

Abstract

The HLA‐DRB1*13:366 allele differs from HLA‐DRB1*13:214 by three nucleotide substitutions in codons 26, 28 and 30 in exon 2.

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Cite This Study

Fan et al. (2026) studied this question.

synapsesocial.com/papers/698433baf1d9ada3c1fb10be https://doi.org/10.1111/tan.70587

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