The 2026 dyslipidemia guideline provides an updated evidence-based approach for managing high cholesterol, hypertriglyceridemia, and elevated lipoprotein(a), replacing the 2018 cholesterol guideline.
This document serves as the updated 2026 comprehensive clinical practice guideline for the management of dyslipidemias, replacing the 2018 version.
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AIM: The "2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia" retires and replaces the "2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol." METHODS: A comprehensive literature search was conducted from October 2024 to December 2024 to identify clinical studies, systematic reviews and meta-analyses, and other evidence conducted on human participants that were published in English from MEDLINE (through PubMed), EMBASE, the Cochrane Library, Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline. STRUCTURE: The focus of this clinical practice guideline is to address the evaluation, management, and monitoring of individuals with dyslipidemias, including high blood cholesterol, hypertriglyceridemia, and elevated lipoprotein(a).
“We’ve known for some time that the time-averaged LDL over your lifetime is the one of the strongest predictors of whether you’re going to get cardiovascular disease.”
This comprehensive new guideline from the ACC and AHA introduces major shifts in the management of cholesterol and lipids to prevent cardiovascular disease, including updated risk assessment tools and more aggressive treatment targets for certain patient populations, sparking widespread discussion on implementation in clinical practice.
Blumenthal et al. (Sun,) reported a other. The 2026 dyslipidemia guideline provides an updated evidence-based approach for managing high cholesterol, hypertriglyceridemia, and elevated lipoprotein(a), replacing the 2018 cholesterol guideline.
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