What question did this study set out to answer?

The aim is to evaluate the impact of hydrogel lens thickness on corneal edema during eye closure periods.

March 21, 2026

Corneal Edema With Hydrogel Lenses and Eye Closure

Key Points

The aim is to evaluate the impact of hydrogel lens thickness on corneal edema during eye closure periods.
Subjects wore hydrogel lenses of two thicknesses (0.07 mm and 0.18 mm) on one eye.
The other eye was treated without a lens during 3-hour eye closure periods.
Corneal edema was measured and compared across the different lens thicknesses.
Corneal edema increased with thicker lenses (12.7%) compared to thinner lenses (7.9%).
Thinner lenses still caused more edema than no lens (0.9%).
Hydrogel lens thickness would need to be under 20 nm to minimize edema during eye closure.

Abstract

Subjects wore hydrogel lenses of two different thicknesses (0.07 mm and 0.18 mm) on one eye and no lens on the other eye during 3‐hour periods of eye closure. They developed more corneal edema (12.7%) with the thicker lenses than with the thinner lenses (7.9%) and more corneal edema with the thinner lenses than with no lens (0.9%). The results suggest that hydrogel lens thickness would have to be less than 20 nm to reduce corneal edema to levels that develop when the eyes are closed without a contact lens.

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