Molecular and physicochemical arrangement of chitosan–ibuprofen matrices for topical drug delivery on skin: preparation impact

Key Points

• This research aims to explore the impact of the preparation process on chitosan-ibuprofen matrices for enhanced topical drug delivery.
• Developed chitosan-ibuprofen matrices through various preparation techniques.
• Evaluated physicochemical properties to determine their impact on drug release.
• Conducted in vitro assessments of drug delivery efficiency on skin models.
• Matrices exhibited altered physicochemical properties based on preparation methods.
• Enhanced drug release rates were observed in optimized matrix formulations.
• Demonstrated potential for improved patient-centric topical applications.